quanterix simoa 2 plex kit  (Quanterix)

Journal: Scientific Reports

Article Title: Quantification of plasma tau species containing the proline-rich region as a biomarker in Alzheimer’s disease

doi: 10.1038/s41598-025-25864-x

Figure Lengend Snippet: Measured levels of ( A ) NfL and ( B ) pTau217-Tau12 in patient samples. Graphs show the distribution of results in CU and AD groups. Quanterix NfL advantage V2 and ALZpath pTau217 kits were used to quantify levels of biomarkers. CU, cognitively unimpaired; AD, Alzheimer’s disease; NfL, neurofilament light. Mann–Whitney U test ( A ) and unpaired t-test with Welch’s correction ( B ) performed for statistical analyses. **** = p < 0.0001. Values expressed as mean ± SEM.

Article Snippet: Standard curve for this assay is displayed in Figure S3 E. Fig. 10 Assessing the performance of T-tau for comparison with P.pAb-P.pAb assay: ( A ) Quanterix tau advantage kit ( B ) P.pAb-P.pAb assay ( C ) Quanterix neurology 3-plex A kit were utilised.

Techniques: MANN-WHITNEY

Journal: Scientific Reports

Article Title: Quantification of plasma tau species containing the proline-rich region as a biomarker in Alzheimer’s disease

doi: 10.1038/s41598-025-25864-x

Figure Lengend Snippet: Assessing the performance of T-tau for comparison with P.pAb-P.pAb assay: ( A ) Quanterix tau advantage kit ( B ) P.pAb-P.pAb assay ( C ) Quanterix neurology 3-plex A kit were utilised. 12-month samples were assessed in ( A ). Baseline samples were assessed in ( B ) and ( C ). Graphs show the distribution of results in CU, AD, AD decliner and AD non-decliner groups. CU, cognitively unimpaired; AD, Alzheimer’s disease; ns, non-significant. Unpaired t-test ( A ) and Mann–Whitney U test ( B ) and ( C ) was performed for statistical analysis. ** = p < 0.0061. Values expressed as mean ± SEM. ( A ) p = 0.82 ( B ) p = 0.0061 (**) ( C ) p = 0.172.

Article Snippet: Standard curve for this assay is displayed in Figure S3 E. Fig. 10 Assessing the performance of T-tau for comparison with P.pAb-P.pAb assay: ( A ) Quanterix tau advantage kit ( B ) P.pAb-P.pAb assay ( C ) Quanterix neurology 3-plex A kit were utilised.

Techniques: Comparison, MANN-WHITNEY